Publications by authors named "L S McGinnis"
Article Synopsis
- Optical pooled screening (OPS) is a method that connects images of cells with genetic changes, but it previously had limitations in its ability to analyze complex data in cancer cell lines.
- The new technology, PerturbView, improves OPS by amplifying genetic barcodes for more detailed and varied phenotype analysis across different biological systems, including stem cells and immune cells.
- PerturbView has unveiled both known and new regulatory mechanisms in immune pathways, and it can be integrated with spatial transcriptomics, enhancing the potential for comprehensive studies of cellular behaviors in complex tissue environments.
Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone. However, there remains little consensus on the mechanism(s) of response with this combination.
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