Publications by authors named "L S Martynenko"
Over the past decades the studies have greatly improved our understanding of the molecular basis of multiple myeloma (MM) and mechanisms of disease progression. The majority of the most widespread chromosomal aberrations, revealing in MM, has independent predictive value and influence on a choice of optimal treatment. There were observed 190 MM patients in hematologic hospitals of St.
View Article and Find Full Text PDFAim: To characterize the clinical and hematological variability of acute myeloid leukemia (AML) with t(8;21) and to identify the signs associated with the likelihood of its relapse.
Subjects And Methods: The results of examining 44 patients aged 11 to 70 years were analyzed; the efficiency of treatment was evaluated in 36. Their karyotypes were studied using the standard GTG method.
Aim: To study the specific features of de novo acute myeloid leukemia (AML) with FLT3-ITD mutation.
Subjects And Methods: The results of examination were analyzed in 101 patients. Bone marrow morphological specimens were stained with Pappenheim stain.
Aim: To analyze the prevalence of chromosome aberrations presented in the revised International Prognostic Scoring System (R-IPSS) in patients with de novo myelodysplastic syndrome (MDS). Subjects and methods. Chromosome aberrations were analyzed in 197 patients aged 14 to 86 years (median age 64 years) with de novo MDS.
View Article and Find Full Text PDFAim: To study distribution of some karyotype variants among patients of different age with acute myeloid leukemia (AML).
Material And Methods: Distribution of balanced, normal, unbalanced, complex and monosomic karyotype among 244 patients with de novo AML in age groups 16-20, 21-30, 31-40, 41-50, 51-60, 61 and older was analysed.
Results: There is difference in frequency of balanced and complex karyotype in patients under and over 60 years.