[Impact of antihypertensive therapy on clinical status and quality of life in patients with initial manifestations of hypertensive encephalopathy].

Aim: To study the clinical and instrumental characteristics of hypertensive encephalopathy (HE) in early stages, as well as the time course of their changes during long-term antihypertensive therapy (AHT).

Subjects And Methods: Prior to and after 9-month AHT, 57 patients aged 50-70 years who had uncomplicated grades 1-2 arterial hypertension (AH) with grades I-II HE underwent comprehensive examination comprising the studies of cognitive functions, quality of life (QL), hemorheology, and hemostasis, duplex scanning of great and intracerebral vessels, echocardiography, 24-hour blood pressure monitoring, magnetic resonance imaging.

Results: Early-stage HE was characterized by more cerebral complaints, higher rates of hypertensive crises, a greater degree of psychoautonomic syndrome, and worse QL.

[Risk factors of vascular brain disorders in patients with diabetes mellitus].

Several studies of patients with diabetes mellitus were analyzed in review. The aim of these studies was to determine the most significant risk factors of vascular brain disorders. The pattern and peculiarities of microvascular disorders which progress simultaneously with changes in brain vessels are discussed.