Publications by authors named "L S Manu"
Background: Few treatments are available for individuals with marked treatment-resistant depression (TRD).
Objective: Evaluate the safety and effectiveness of FDA-approved adjunctive vagus nerve stimulation (VNS) in patients with marked TRD.
Methods: This 12-month, multicenter, double-blind, sham-controlled trial included 493 adults with marked treatment-resistant major depression who were randomized to active or no-stimulation sham VNS for 12 months.
Background: Depression treatments aim to minimize symptom burden and optimize quality of life (QoL) and psychosocial function.
Objective: Compare the effects of adjunctive versus sham vagus nerve stimulation (VNS) on QoL and function in markedly treatment-resistant depression (TRD).
Methods: In this multicenter, double-blind, sham-controlled trial, 493 adults with TRD and ≥4 adequate but unsuccessful antidepressant treatment trials (current episode) were randomized to active (n = 249) or sham (n = 244) VNS (plus treatment as usual) over a 12-month observation period.
Article Synopsis
- Cervical cancer screening in low-resource settings is mostly opportunistic and underutilized, as many women only seek health care during pregnancy or after childbirth.
- A study conducted at Catholic Hospital, Battor assessed cervical screening during antenatal and postnatal visits, with a significant sample of 270 pregnant women and 107 postnatal women tested for hr-HPV and underwent visual examinations.
- The findings showed a 25.5% prevalence of hr-HPV, and a VIA positivity rate of 5.3%, illustrating that utilizing ANC and PNC clinics can effectively improve cervical cancer screening rates in these communities.
Background: The need for cervical cancer screening has been emphasised in at-risk cohorts of women to reduce their risk of cervical cancer. Some women with decreased risk of acquiring human papillomavirus (HPV) infections, such as Catholic nuns, receive less attention and on occasion are missed in cervical cancer screening programmes. This study aimed to determine the high-risk HPV (hr-HPV) prevalence in such a cohort to emphasise the need for cervical precancer screening among all women.
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