Publications by authors named "L S M Boesten"
Article Synopsis
- * The study involved a prospective cohort of 611 participants aged 16 and older with at least 5 years of T1D, plus a second group of 160 participants with a minimum of 35 years of T1D, gathering a range of health data, physical assessments, and biological samples.
- * Preliminary findings indicate that additional C-peptide secretion was noted in 10% of individuals, linking fasting C-peptide levels with reduced hypoglycemia awareness
Article Synopsis
- The study evaluated how stable C-peptide levels are over time in individuals with long-standing type 1 diabetes, focusing on both fasting C-peptide and responses after a mixed-meal tolerance test (MMTT).
- Among 607 participants, only 25% showed detectable fasting C-peptide, with levels significantly decreasing over one year, and patients with higher levels were generally diagnosed at an older age and had shorter disease duration.
- The findings indicated that stimulated C-peptide was found in 10% more participants during MMTT compared to fasting tests, and results from MMTT at 90 and 120 minutes closely matched overall C-peptide area under the curve measurements.
Context: Measurements of thyroglobulin (Tg) and Tg antibodies are crucial in the follow-up of treated differentiated thyroid cancer (DTC) patients. Interassay differences may significantly impact follow-up.
Objective: The aim of this multicenter study was to explore the impact of Tg and Tg antibody assay performance on the differential classification of DTC patients, as described in national and international guidelines.
Article Synopsis
- C-peptide is a key marker for assessing insulin production in type 1 diabetes (T1D), and accurate assays are essential for detecting tiny changes over time.
- A study compared two assays: the ultrasensitive Mercodia ELISA and Beckman IRMA, focusing on their performance in measuring low C-peptide levels.
- The Beckman IRMA showed better quantification capability than the Mercodia ELISA, emphasizing the need for establishing limits of quantification in assays before their use in research and clinical settings.
Article Synopsis
- The study investigated the link between fasting serum C-peptide levels and impaired awareness of hypoglycemia (IAH) in individuals with type 1 diabetes, involving data from 509 patients.
- 25% of participants showed residual C-peptide secretion, and 15% reported IAH; lower severe hypoglycemia was noted in those with C-peptide presence.
- The analysis indicated that higher age, longer diabetes duration, and various complications increased the risk of IAH, while residual C-peptide was linked to a lower prevalence of it.