STUDYING THE PHYSICAL DEPENDENCE ON AND TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF RU-1205 SUBSTANCE.

We have studied the physical dependence on and tolerance to the analgesic activity of compound RU-1205. It is established that this compound does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.

[Morphological changes in pulmonary alveolus macrophages as affected by alcohol and nitrosodimethylamine].

Comparative electron microscopic studies of lung alveolar macrophage (LAM) ultrastructure (with their surface architectonics) were performed in transmission and scan regimen in 3 groups of animals: in intact rats and in rats 12 and 24 hours after a single intragastric administration of nitrosodimethylamine at a concentration of 30 mg/kg in one case and of 50% ethanol (2 ml per 100 g animal weight) in the other case. The transformation of cytoplasmic excrescences, manifested in their diminution, twisting and fusion resulted in the formation of fold-hilly LAM surface. The data obtained may be used for the elaboration of criteria for the assessment of environmental effects of toxic factors.