[A variant of p.Arg1623Gln of the DYNC1H1 gene in a patient with corpus callosum agenesis, polydactyly, mental development disorder, and neuromuscular system disorders].

encodes the heavy chain of dynein 1, a protein that plays a critical role in intracellular transport and is also involved in neurogenesis, bipolar spindle apparatus formation, and interaction with certain regulatory proteins. Many variants of the gene are described in various neuromuscular, psychoneurological, congenital abnormalities, and malignancies. In this clinical case, the correlation of clinical manifestations with molecular genetic changes of the gene was evaluated.

Oxidative Coupling of Guanidines and Isocyanides Catalyzed by Nickel(II): Access to Imidazoline Derivatives with Antibacterial Activity.

A novel and concise approach to rare 2,3,5-triamino-imidazole scaffolds via Ni-catalyzed coupling of alkylisocyanides and N,N'-diarylguanidines has been developed. This reaction features include mild conditions (thermal or visible light activation), a wide substrate scope, and high efficiency. The coupling proceeds through a Ni/Ni catalytic cycle, involving two-electron aerobic oxidation and the sequential insertion of two isocyanide units into Ni-N bonds.

You Win Some, You Lose Some: Modifying the Molecular Periphery of Nitrofuran-Tagged Diazaspirooctane Reshapes Its Antibacterial Activity Profile.

The use of the concept of privileged structures significantly accelerates the search for new leads and their optimization. 6-(methylsulfonyl)-8-(4-methyl-4-1,2,4-triazol-3-yl)-2-(5-nitro-2-furoyl)-2,6-diazaspiro[3.4]octane has been identified as a lead, with MICs of 0.

Fabrication of biocidal materials based on the molecular interactions of tetracycline and quercetin with hydroxyapatite via and In vitro approaches.

Synthetic hydroxyapatite (HA) materials with antibacterial and biocompatible properties have potential for biomedical applications. The application of various computational methods is highly relevant for the optimal development of modern materials. In this work, we used molecular docking to determine the binding constants of tetracycline (TET) and quercetin (QUE) with hydroxyapatite and compared them to experimental data of the adsorption of tetracycline (TET) and quercetin (QUE) on the HA surface.

[The use of the combined drug Urolife-Next for recurrent lower urinary tract infections: clinical and microbiological aspects].

Background: Improving the efficiency of treatment and prevention of recurrent lower urinary tract infection (LUTI) is an important problem in modern urology. A significant role is given to the non-antibiotic measures.

Aim: To evaluate the clinical and microbiological efficiency of the drug Urolife-Next in patients with recurrent UTI.