Publications by authors named "L S Hammond"
Purpose: We report the qualitative findings from a survey of elementary teachers regarding reading instruction. The purpose is to extend on quantitative findings in a previously described survey to gain a more in-depth understanding of Australian elementary teachers' approaches to the literacy block in their schools: how this is used, who makes instructional decisions, and how teachers respond to these.
Method: A web-based survey was used to collect data from Australian elementary teachers about their perspectives regarding reading comprehension instruction.
Human-specific (HS) genes have been implicated in brain evolution, but their impact on human neuron development and diseases remains unclear. Here, we study SRGAP2B/C, two HS gene duplications of the ancestral synaptic gene SRGAP2A, in human cortical pyramidal neurons (CPNs) xenotransplanted in the mouse cortex. Downregulation of SRGAP2B/C in human CPNs led to strongly accelerated synaptic development, indicating their requirement for the neoteny that distinguishes human synaptogenesis.
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- This study analyzes the early and mid-stages of Alzheimer's disease by profiling gene and protein expressions in a human APP knock-in model to understand how amyloid-beta (Aβ) affects brain cells.
- It explores the role of TREM2, a gene linked to Alzheimer's risk, by comparing its effects in App mice with TREM2 knockout models, emphasizing how TREM2 influences microglial responses to Aβ.
- The findings reveal that Aβ deposition leads to changes in microglial activation, energy metabolism, and protein synthesis, indicating potential therapeutic targets for Alzheimer's disease by addressing these molecular mechanisms.
Article Synopsis
- Horseshoes significantly affect the safety and performance of racehorses by providing necessary traction while managing hoof slip, which can help reduce stress and potential injuries.
- The study measured hoof slip duration in retired Thoroughbreds galloping on turf and artificial tracks with different shoeing setups using high-speed video, analyzing data from 389 hoof interactions.
- Findings revealed that slip duration varied among shoeing conditions and surfaces, with the leading hindlimb typically having the shortest slip duration, while turf generally resulted in longer slip durations for most limbs compared to artificial track surfaces.
Quantification of Dosimetry Improvement With or Without Patient Surface Guidance.
Adv Radiat Oncol
September 2024
Purpose: Noncoplanar beams and arcs are routinely used to improve dosimetry for intracranial cases, but their application for extracranial cases has been hampered by the risk of collision. This has led to conservative beam selection whose impact on plan dosimetry has not been previously studied.
Methods And Materials: A full-body 3-dimensional patient surface was acquired using optical cameras for a single lung patient at the time of computed tomography simulation.