In 1.5 months after modeling of streptozotocin-induced diabetes mellitus, superoxide dismutase and catalase activities decreased by 40.7 and 32.
View Article and Find Full Text PDFEksp Klin Farmakol
September 2015
The characteristics of visual evoked potential (VEP) have been investigated in a group of 15 healthy volunteers (aged 31.7 ± 3.6 years) and 30 insulin-dependent patients (aged 32.
View Article and Find Full Text PDFBull Exp Biol Med
June 2009
The development of tolerance in rats by repeated intraperitoneal injection of 0.5 mg/kg diazepam increased the sensitivity of the frontal cortex to the epileptogenic effect of NMDA and kainic acid. The median effective dose of NMDA was shown to decrease under these conditions.
View Article and Find Full Text PDFIntracerebroventricular injection of recombinant human interferon-2alpha (100-500 U/rat) decreased the mean effective dose of corasol inducing clonic convulsions in 50% kindled Wistar rats. This effect was more pronounced in delayed periods of kindling and was accompanied by enhancement of epileptiform signs on EEG.
View Article and Find Full Text PDFNeurosci Behav Physiol
March 2005
Acute experiments were performed on rats to produce a model of chronic epileptic activity--pharmacological kindling by repeated doses of picrotoxin (1.0-1.2 mg/kg, i.
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