Publications by authors named "L S Fonacier"
Recognizing and Managing Allergic Contact Dermatitis: Focus on Major Allergens.
J Allergy Clin Immunol Pract
September 2024
Patch testing is the reference standard for the diagnosis of allergic contact dermatitis. Identification and avoidance of culprit allergens are essential in the treatment of this disease. Each year, new allergens are identified as emerging or important.
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- Angioedema (AE) is a condition characterized by localized swelling in the skin or mucous membranes and can be hereditary or acquired, making its classification complex due to various underlying mechanisms and taxonomies.
- The DANCE initiative, involving 91 experts from 35 countries, aimed to create a unified consensus on the definition, acronyms, and classification of AE through an extensive online discussion and voting process over 16 months.
- The resulting DANCE classification introduces five types of AE, standardizes terminology, and is designed to enhance research and patient care while complementing existing clinical guidelines without replacing them.
Article Synopsis
- The study investigated the effectiveness and safety of the medication abrocitinib for treating moderate-to-severe atopic dermatitis, focusing on different racial and ethnic groups.
- Data from three trials included self-reported race and ethnicity, as well as Fitzpatrick skin type, to compare responses to the treatment.
- Results showed that abrocitinib significantly improved skin conditions for all racial groups, with the most pronounced effects in White patients; however, Black patients had similar responses to both doses tested and reported more treatment-related side effects compared to Asian patients.
Background: Abrocitinib, an oral, once-daily Janus kinase 1-selective inhibitor, improved itch severity, sleep, and work productivity versus placebo in patients with moderate-to-severe atopic dermatitis.
Objective: The aim of this study was to investigate relationships among itch, sleep, and work productivity in the phase III JADE MONO-2 clinical trial.
Methods: A repeated-measures longitudinal model was used to examine relationships between itch (using the Peak Pruritus Numerical Rating Scale [PP-NRS] or Nighttime Itch Scale [NTIS]) and sleep disturbance/loss (using the Patient-Oriented Eczema Measure sleep item and SCORing AD Sleep Loss Visual Analog Scale) and, separately, between itch and work productivity (using the Work Productivity and Activity Impairment-Atopic Dermatitis Version 2.