eIF3 engages with 3'-UTR termini of highly translated mRNAs.

Stem cell differentiation involves a global increase in protein synthesis to meet the demands of specialized cell types. However, the molecular mechanisms underlying this translational burst and the involvement of initiation factors remains largely unknown. Here, we investigate the role of eukaryotic initiation factor 3 (eIF3) in early differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (NPCs).

Subclinical depressive symptoms and job stress differentially impact memory in working and retired older adults.

Retirement has been associated with cognitive decline beyond normal age-related decline. However, there are many individual differences in retirement that can influence cognition. Subclinical depressive symptoms are common in late life and are associated with general memory decline and a bias towards remembering negative events (i.

Relative effectiveness of the second booster COVID-19 vaccines against laboratory confirmed SARS-CoV-2 infection in healthcare workers: VEBIS HCW VE cohort study (1 October 2022-2 May 2023).

Introduction: Repeated COVID-19 booster vaccination was recommended in healthcare workers (HCWs) to maintain protection. We measured the relative vaccine effectiveness (rVE) of the second booster dose of COVID-19 vaccine compared to the first booster, against laboratory-confirmed SARS-CoV-2 infection in HCWs.

Methods: In a prospective cohort study among HCWs from 12 European hospitals, we collected nasopharyngeal or saliva samples at enrolment and during weekly/fortnightly follow-up between October 2022 and May 2023.

High and low current perceived stress associated with enhanced emotional mnemonic discrimination.

Stress can have profound impacts on memory. However, the directionality of stress effects on memory varies widely across studies, some showing enhancement while others showing impairment. This variability has been attributed to the Yerkes-Dodson Law, which proposes a U-shaped pattern such that too little or too much stress may be associated with cognitive dysfunction.

Advocating for Paid Maternity Leave and Workplace Lactation Policy Reform and Implementation: Lessons Learned From Indonesia, Nigeria, the Philippines and Vietnam.

Maternity protection policies are designed to preserve the health of working women and their infants, support optimal infant and young child nutrition through breastfeeding and prevent workplace discrimination against women. The aim of this study was to identify how advocates may be able to effectively advance maternal leave and workplace lactation policies, two key maternity protection policies, and does so through an exploration of advocacy efforts in Indonesia, Nigeria, the Philippines and Vietnam. A desk review of programme and policy documents and 20 key informant interviews with diverse stakeholders explored advocacy efforts in each of the four countries.