Publications by authors named "L S Czer"
Background: Primary graft dysfunction (PGD) remains the leading cause of 30-day mortality post-heart transplantation (HTx). HTx recipients experiencing severe PGD have been found to have high levels of circulating proteins associated with PGD occurrence and post-HTx survival. Whether treating these patients with therapeutic plasma exchange (TPE) can attenuate ongoing immunological and inflammatory processes and improve post-transplant outcomes has not been well-investigated.
View Article and Find Full Text PDFBackground: Appropriate anticoagulation is crucial for the success of left ventricular assist device patients. Currently, there is no consensus on the optimal management of their subtherapeutic INR in ambulatory setting. Our goal is to evaluate both the short-term adverse events and long-term outcomes of enoxaparin bridging at a major transplant center, following the implementation of bridging safety criteria.
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- Bortezomib, a proteasome inhibitor, was evaluated alongside plasmapheresis as a method to desensitize highly sensitized heart transplant patients (cPRA > 50%) at a single center from 2010 to 2021, with a focus on their outcomes compared to non-sensitized patients.
- Despite some changes in antibody levels, the desensitization therapy did not lead to a statistically significant decrease in overall sensitization (mean cPRA remained high), though there was a marginally better response in class I antibodies compared to class II.
- While one-year survival rates were similar between desensitized patients and non-sensitized controls (95.4% vs. 92
Heart transplantation in patients from socioeconomically distressed communities.
J Heart Lung Transplant
February 2024
Background: Studies examining heart transplantation disparities have focused on individual factors such as race or insurance status. We characterized the impact of a composite community socioeconomic disadvantage index on heart transplantation outcomes.
Methods: From the Scientific Registry of Transplant Recipients (SRTR), we identified 49,340 primary, isolated adult heart transplant candidates and 32,494 recipients (2005-2020).
Background: Given ongoing donor shortages, appropriate patient selection for dual-organ transplantation is critical. We evaluated outcomes of heart retransplant with simultaneous kidney transplant (HRT-KT) vs isolated heart retransplant (HRT) across varying levels of renal dysfunction.
Methods: The United Network for Organ Sharing database identified 1189 adult patients undergoing heart retransplantation between 2005 and 2020.