Publications by authors named "L S Couch"
Article Synopsis
- The study explores the assessment of coronary microvascular dysfunction (CMD) using a new hybrid index derived from pressure-wire measurements and angiography, promoting its potential use in clinical settings.
- Researchers compared this hybrid index, known as IMR, with a traditional bolus thermodilution-based index in a cohort of patients with acute coronary syndrome and stable coronary artery disease.
- Results indicate that both the new hybrid IMR and the traditional index showed strong correlations and diagnostic accuracy for CMD, suggesting IMR is a simpler and effective alternative for routine clinical use.
Article Synopsis
- Peripheral nerve injury is linked to Charcot-Marie-Tooth (CMT) disease, which mainly causes progressive muscle weakening, especially noticeable during adolescence or early adulthood.
- The case study describes an 81-year-old woman experiencing urinary tract infections, abdominal pain, constipation, and dysuria along with abnormal electrolyte levels.
- An effective symptomatic treatment plan is presented for managing the issues related to this rare neuromuscular disorder in the patient.
Article Synopsis
- Alcohol can be used to cope with physical pain and negative emotions, but this can lead to harmful drinking habits.
- A study tested 82 people, including those who drink heavily and those who drink socially, to see how their brains respond when trying to avoid pain while learning.
- The study found that people with alcohol problems had trouble avoiding pain and their brain activity showed different reactions when using alcohol to escape negative feelings versus physical pain.
Article Synopsis
- Immunological therapies, including immune checkpoint inhibitors (ICIs) and cell-based therapies like CAR-T, have transformed cancer treatment by enabling the immune system to target cancer cells.
- While these therapies are generally effective, they can cause immune-related adverse events (irAEs) that vary in severity and timing, from mild skin rashes to serious complications such as myocarditis or cytokine release syndrome.
- The statement discusses the growing understanding of cardiovascular toxicities associated with these therapies, outlines their diagnosis and management, and identifies gaps in current research that need further exploration.
Aims: The trials upon which recommendations for the use of cardiac resynchronization therapy (CRT) in heart failure used optimal medical therapy (OMT) before sodium-glucose co-transporter 2 inhibitors (SGLT2i). Moreover, the SGLT2i heart failure trials included only a small proportion of participants with CRT, and therefore, it remains uncertain whether SGLT2i should be considered part of OMT prior to CRT.
Methods And Results: We compared electrocardiogram (ECG) and echocardiographic responses to CRT as well as hospitalization and mortality rates in consecutive patients undergoing implantation at a large tertiary centre between January 2019 to June 2022 with and without SGLT2i treatment.