FBXO38 is dispensable for PD-1 regulation.

SKP1-CUL1-F-box protein (SCF) ubiquitin ligases are versatile protein complexes that mediate the ubiquitination of protein substrates. The direct substrate recognition relies on a large family of F-box-domain-containing subunits. One of these substrate receptors is FBXO38, which is encoded by a gene found mutated in families with early-onset distal motor neuronopathy.

FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.

Alterations in the gene encoding the E3 ubiquitin ligase substrate receptor FBXO38 have been associated with several diseases, including early-onset motor neuronopathy. However, the cellular processes affected by the enzymatic action of FBXO38 are not yet known. Here, we identify the zinc finger proteins ZXDA/B as its interaction partners.

FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation.

The ubiquitin ligase SCF controls centromeric chromatin by promoting the degradation of the ZXDB protein. To determine the importance of this pathway during development, -deficient mice were generated. The loss of FBXO38 resulted in growth retardation affecting several organs, including the male reproductive system.

Effect of housing system and feed restriction on meat quality of medium-growing chickens.

The aim of the study was to evaluate the differences in meat quality of 420 Hubbard JA757 cockerels in relation to the housing system (litter and mobile box) and level of mixed feed (ad libitum [AL], reducing the level by 20% [R20] and 30% [R30]). Three groups of chickens were housed in litter boxes for the entire fattening period (stocking density: 0.094 m/bird).