Unplanned extubation prevention in the neuroscience ICU at a High Reliability Organization.

Background: Intubated neuroscience ICU patients are at risk for unplanned extubation (premature removal of the endotracheal tube by the patient or during patient care). The incidence of unplanned extubation is an indicator of the quality of ICU care. Unplanned extubation is a risk factor for pneumonia, increased ventilator days, the need for tracheostomy and increased ICU and hospital length-of-stay.

An Industry Perspective on the Use of Novel Excipients in Lipid Nanoparticles-Nonclinical Considerations.

Nucleic acid drug delivery with lipid nanoparticle (LNP) formulations has enabled the development of novel therapeutics and vaccines. LNP formulations are composed of both naturally occurring and synthetic lipid excipients. This perspective shares current practices in the nonclinical safety assessment of novel lipid excipients contained in LNP formulations and identifies gaps in current regulatory guidance on this topic.

Nurse retention in peri- and post-COVID-19 work environments: a scoping review of factors, strategies and interventions.

Objectives: The COVID-19 pandemic highlighted the deterioration of nurses' working conditions and a growing global nursing shortage. Little is known about the factors, strategies and interventions that could improve nurse retention in the peri- and post-COVID-19 period. An improved understanding of strategies that support and retain nurses will provide a foundation for developing informed approaches to sustaining the nursing workforce.

A high resolution multipollutant assessment of health damages due to the onroad sector in Boston, Massachusetts.

Onroad vehicular emissions can adversely affect the health of people both near-road and regionally through exposure to O, NO and PM. While multiple studies have characterized the overall air quality and health benefits of emissions from the transportation sector, fewer studies have modeled the benefits of transportation policies at higher geographic resolution relevant to communities. We used the United States Environmental Protection Agency (U.