Publications by authors named "L Ruterbories"
Background: Comparative pharmacokinetics and pharmacodynamics (PK/PD) of apixaban and rivaroxaban have not been studied in dogs and the propensity of these drugs to cause hypercoagulability after discontinuation is unknown.
Hypothesis: Compare the PK/PD of clinical dosing regimens of PO apixaban and rivaroxaban administered repeatedly to healthy dogs and assess the effect of abrupt drug discontinuation on coagulation.
Animals: Six University-owned, purpose-bred, middle-aged, mixed-breed dogs (4 male, 2 female).
Thromboelastography (TEG) is a hemostatic assay evaluating clot initiation time, kinetics, strength, and extent of fibrinolysis. Hemostatic assays in nonmammalian species have been less extensively studied because of lack of taxon-specific reagents and unique physiology. Hemostatic or hemorrhagic disease has been described postmortem in elasmobranchs, but antemortem detection of coagulopathies is limited in this taxon.
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- Elephant endotheliotropic herpesvirus (EEHV) causes rapid and fatal hemorrhagic disease in African elephants, underscoring the need for early diagnostic tools.
- A study evaluated a new point-of-care viscoelastic coagulation monitor (VCM Vet) against traditional thromboelastography (TEG) to assess clotting in healthy adult African elephants.
- Both VCM Vet and TEG provided similar results for clot formation, strength, and lysis, indicating that VCM Vet could be a reliable tool for diagnosing EEHV-HD before severe clinical signs appear.
Background: No treatment other than platelet administration is known to protect against spontaneous hemorrhage in thrombocytopenic dogs.
Objectives: Primary: determine if treatment with ε-aminocaproic acid (EACA) decreases the requirement for blood transfusions and improves outcome in dogs with severe thrombocytopenia. Secondary: find evidence of hyperfibrinolysis and determine the effect EACA administration on rapid (rTEG) and tissue plasminogen activator-spiked (tPA-rTEG) thromboelastography parameters.
Introduction: The antiplatelet effect of clopidogrel can vary between patients. A modified thromboelastography (TEG) protocol (TEG-Platelet Mapping assay [TEG-PM]) can be used for clopidogrel monitoring but is not widely available. Thrombin generation (TG) assays could offer a novel alternative.
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