Publications by authors named "L Rueda-Delgado"
Article Synopsis
- * It analyzed over 1000 participants from ages 14 to 23 to determine if issues with sustained attention predict future substance use rather than being just a side effect.
- * The results showed that strong brain connections related to sustained attention at age 14 can predict an increase in cannabis and cigarette use later, highlighting sustained attention as a key indicator of vulnerability to substance use.
Article Synopsis
- Ketamine, a dissociative anesthetic, alters global consciousness states and brain dynamics, with the study investigating its effects using portable low-density EEG systems instead of traditional methods.
- The study involved 30 male adults in a double-blinded experiment comparing ketamine and saline, analyzing both resting-state and task-driven EEG, finding that ketamine increases redundancy in brain dynamics, especially at alpha frequencies.
- High-order interactions (HOI) revealed that ketamine correlates with dissociative experiences and offers a novel approach to studying brain connectivity and dynamics during drug interventions.
Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance-use or a marker of the inclination to engage in such behaviour. This study explored the relationship between sustained attention and substance use across a longitudinal span from ages 14 to 23 in over 1,000 participants.
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- A study involving 30 young adult males utilized a double-blinded crossover design to investigate the effects of racemic ketamine compared to saline infusion on brain dynamics through EEG recordings.
- Ketamine was found to increase redundancy in brain activity, especially in the alpha frequency band, and this effect was more pronounced in a resting state, indicating a shift towards dissociative states of consciousness.
- The study introduces Higher Order Interactions (HOI) as a promising method for analyzing EEG data, highlighting its capability to reveal how different electrode interactions may be associated with experiences like derealization and changes in consciousness due to drug interventions.
Recent advances have enabled the creation of wireless, "dry" electroencephalography (EEG) recording systems, and easy-to-use engaging tasks, that can be operated repeatedly by naïve users, unsupervised in the home. Here, we evaluated the validity of dry-EEG, cognitive task gamification, and unsupervised home-based recordings used in combination. Two separate cohorts of participants-older and younger adults-collected data at home over several weeks using a wireless dry EEG system interfaced with a tablet for task presentation.
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