Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems.

The interaction of the anticancer Ru(iii) complex AziRu - in comparison with its analogue NAMI-A, currently in advanced clinical trials as an antimetastatic agent - with DNA model systems, both single stranded and duplex oligonucleotides, was investigated using a combined approach, including absorption UV-vis spectroscopy, circular dichroism (CD) and electrospray mass spectrometry (ESI-MS) techniques. UV-vis absorption spectra of the Ru complexes were recorded at different times in a pseudo-physiological solution, to monitor the ligand exchange processes in the absence and in the presence of the examined oligonucleotides. CD experiments provided information on the overall conformational changes of the DNA model systems induced by these metal complexes.

Isolated hypoglossal nerve palsy due to an anomalous vertebral artery course: report of two cases.

The authors report two patients with isolated unilateral tongue atrophy. Magnetic resonance imaging (MRI) of the brain stem and angio-MRI demonstrated a dolichovertebral artery with an abnormal course compressing the medulla oblongata at the emergence of the hypoglossal rootlets. The semeiological observation of a sectorial and not uniform distribution of atrophy in the half-affected tongue is discussed in relation to the lesional site.

Median nerve middle-long latency somatosensory evoked potentials in children with tactile evoked spikes.

It is known that hand tapping during electroencephalography (EEG) recording evokes centrotemporal spikes in some 4- to 12-year-old children. This phenomenon occurs in both healthy and epileptic children. The same children were reported to show giant middle-long latency evoked potentials (MLSEPs).

Telephone transmission of 20-channel digital electroencephalogram using lossless data compression.

Background: The use of telecommunications for computer-assisted transmission of neurophysiological signals is a relatively new practice. With the development of digital technology, it is now possible to record electroencephalograms (EEGs) in digital form. Previous reports have demonstrated the possibility of real-time telephone transmission of a limited number of EEG channels.