Pharmacokinetics of intravenously administered digoxin and histopathological picture in rabbits with experimental bile duct obstruction.

This study aimed to examine the effect of obstructive cholestasis on the pharmacokinetics of digoxin. Eighteen male rabbits were randomly ascribed to the two study groups: the sham-operated control group and the examined group - with common and cystic bile duct ligations. Digoxin was administered intravenously as a single dose of 0.

Pharmacokinetics of intragastrically administered digoxin in rabbits with experimental bile duct obstruction.

A change in the functioning of the liver as a result of experimental cholestasis could result in a change in the biotransformation of drugs. The aim of this study was to evaluate the effect of extrahepatic cholestasis on the pharmacokinetics of digoxin. The investigation was performed on male rabbits randomly divided into two groups: sham-operated and animals with bile-duct ligation.

Effect of lecithin on the development of experimental atherosclerosis in rabbits.

Thirty male mongrel rabbits were divided into 3 equal groups: (1) controls, (2) animals receiving a high-fat diet (HFD) containing cholesterol and coconut oil, and (3) HFD + lecithin. The experiment lasted 12 weeks. In animals receiving a HFD (group II) the QRS interval (ECG) was significantly prolonged, and the concentration of lipid fractions (except for HDL-cholesterol) and malondialdehyde (MDA) in the blood was markedly elevated.

Pharmacokinetics of phenazone (antipyrine) in rabbits with experimental common bile duct obstruction.

1. An altered functional state of liver due to experimental cholestasis could result in a change in the biotransformation of drugs. The aim of this study was to evaluate an influence of obstructive cholestasis on the pharmacokinetics of phenazone (antipyrine).

Extractum Fagopyri reduces atherosclerosis in high-fat diet fed rabbits.

A group of 30 male mongrel rabbits was divided into 3 subgroups: controls, animals receiving a high-fat diet (HFD) containing cholesterol and coconut oil, HFD + Extr. Fagopyri (EF) were treated for 12 weeks. Surface areas of lipid deposites after 12 weeks of treatment measured planimetrically in the intima of the aorta, averaged 86.