Publications by authors named "L Roveri"
Article Synopsis
- The study examines how general anesthesia (GA) compares to conscious sedation/local anesthesia (CS/LA) in patients with minor strokes undergoing immediate mechanical thrombectomy (iMT).
- The research involved analyzing data from 16 stroke centers, focusing on patients with isolated M2 occlusions and mild stroke severity, utilizing propensity score matching for a fair comparison.
- Results showed no significant difference in patient outcomes or complications between those receiving GA or CS/LA, indicating that the choice of anesthesia does not impact recovery or procedural safety in these cases.
Staphylococcus aureus modulates the host immune response directly by interacting with the immune cells or indirectly by secreting molecules (secretome). Relevant differences in virulence mechanisms have been reported for the secretome produced by different S. aureus strains.
View Article and Find Full Text PDFAging accounts for increased risk and dismal outcome of ischemic stroke. Here, we investigated the impact of age-related changes in the immune system on stroke. Upon experimental stroke, compared with young mice, aged mice had increased neutrophil clogging of the ischemic brain microcirculation, leading to worse no-reflow and outcomes.
View Article and Find Full Text PDFBackground: Patients with minor stroke and M2 occlusion undergoing best medical management (BMM) may face early neurological deterioration (END) that can lead to poor long-term outcome. In case of END, rescue mechanical thrombectomy (rMT) seems beneficial. Our study aimed to define factors relevant to clinical outcome in patients undergoing BMM with the possibility of rMT on END, and find predictors of END.
View Article and Find Full Text PDFBackground: The purpose of this study was to evaluate the effectiveness of mechanical thrombectomy (MT) in patients with isolated M2 occlusion and minor symptoms and identify possible baseline predictors of clinical outcome.
Methods: The databases of 16 high-volume stroke centers were retrospectively screened for consecutive patients with isolated M2 occlusion and a baseline National Institutes of Health Stroke Scale (NIHSS) score ≤5 who received either early MT (eMT) or best medical management (BMM) with the possibility of rescue MT (rMT) on early neurological worsening. Because our patients were not randomized, we used propensity score matching (PSM) to estimate the treatment effect of eMT compared with the BMM/rMT.