Clastogenic effects of heroin in pregnant monkeys and their offspring.

Heroin was administered daily i.v. to pregnant Macaca mulatta monkeys, for 3 months, and after birth of their babies, was continued for 3 months post-partum.

The relevance of the structural co-factor (chemogenic lesion) in adverse and toxic reactions of neuropsychotropic agents.

1. Multidisciplinary methodologies in human and experimental investigations revealed that neuropsychotropic agents display multiple neural and extraneural "targets" or bioreceptors. 2.

Effects of methadone hydrochloride on the growth of organotypic cerebellar cultures prepared from methadone-tolerant and control rats.

Male and female Sprague-Dawley rats were given dl-methadone (5 mg/kg) for at least 3 months and then mated. The drug was continued throughout pregnancy and after delivery. The newly born pups were divided into two groups.