Publications by authors named "L Roisman"

Blue light reflectance (BLR) imaging offers a non-invasive, cost-effective method for evaluating retinal structures by analyzing the reflectance and absorption characteristics of the inner retinal layers. By leveraging blue light's interaction with retinal tissues, BLR enhances visualization beyond the retinal nerve fiber layer, improving detection of structures such as the outer plexiform layer and macular pigment. Its diagnostic utility has been demonstrated in distinct retinal conditions, including hyperreflectance in early macular telangiectasia, hyporeflectance in non-perfused areas indicative of ischemia, identification of pseudodrusen patterns (notably the ribbon type), and detection of peripheral retinal tears and degenerative retinoschisis in eyes with reduced retinal pigment epithelial pigmentation.

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Background: Over the past decade, progress in the diagnosis and treatment of Non-Small Cell Lung Cancer (NSCLC) has led to the identification of many targeted mutations. This has enhanced PFS and OS in both advanced and early-stage NSCLC. The current standard of care for stage III NSCLC varies, and it may combine chemotherapy with either immunotherapy or radiotherapy.

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Bullous serous central chorioretinopathy (bCSCR) is an atypical form of CSCR characterized by large serous detachment. This variant presents significant diagnostic challenges, and optimal treatment strategies are not well defined. This report presents a case of a 31-year-old man with bCSRC treated with scleral thinning surgery in four quadrants with scleral windows created in the two inferior quadrants.

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Design: A retrospective, cross-sectional image analysis using a convenience sample.

Subjects: Five cases selected based on the availability of comprehensive imaging data.

Methods: This study involved a retrospective review of images from five cases, focusing on the use of retinal monochromatic blue light reflectance (BLR) imaging to detect non-perfusion areas.

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Article Synopsis
  • Vitamin C (L-ascorbic acid) is essential in human health, acting as an antioxidant and aiding enzymatic processes, especially when used in high doses intravenously for cancer treatment.
  • A case study involving a 68-year-old man with unresectable hepatocellular carcinoma (HCC) showed that adding high-dose intravenous Vitamin C to his current treatment of atezolizumab and bevacizumab led to significant health improvements, including reduced tumor markers and improved liver function.
  • This combination therapy is the first of its kind documented, showing safety and effectiveness, but further research is suggested to fully understand its potential in treating HCC.
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