LAM Test: A New Cognitive Marker for Early Detection in Preclinical Alzheimer's Disease.

Background: With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive to Alzheimer's disease (AD) pathology in preclinical stages.

Objective: To determine the utility of a newly developed Learning and Associative Memory face test: LAM test. This study examined the relationship between AD cerebrospinal fluid (CSF) biomarkers and performance on LAM test, and assessed its potential clinical applicability to detect subtle changes in cognitively healthy subjects at risk for AD.

Identification of hypermucoviscous Klebsiella pneumoniae K1, K2, K54 and K57 capsular serotypes by Raman spectroscopy.

Antimicrobial resistance poses a significant challenge in modern medicine, affecting public health. Klebsiella pneumoniae infections compound this issue due to their broad range of infections and the emergence of multiple antibiotic resistance mechanisms. Efficient detection of its capsular serotypes is crucial for immediate patient treatment, epidemiological tracking and outbreak containment.

Non-Contact Thermal and Acoustic Sensors with Embedded Artificial Intelligence for Point-of-Care Diagnostics.

This work involves exploring non-invasive sensor technologies for data collection and preprocessing, specifically focusing on novel thermal calibration methods and assessing low-cost infrared radiation sensors for facial temperature analysis. Additionally, it investigates innovative approaches to analyzing acoustic signals for quantifying coughing episodes. The research integrates diverse data capture technologies to analyze them collectively, considering their temporal evolution and physical attributes, aiming to extract statistically significant relationships among various variables for valuable insights.

Design and Verification of Integrated Circuitry for Real-Time Frailty Monitoring.

In this study, a new wireless electronic circuitry to analyze weight distribution was designed and incorporated into a chair to gather data related to common human postures (sitting and standing up). These common actions have a significant impact on various motor capabilities, including gait parameters, fall risk, and information on sarcopenia. The quality of these actions lacks an absolute measurement, and currently, there is no qualitative and objective metric for it.

Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions.

Photodynamic therapy (PDT) is an increasingly popular dermatological treatment not only used for life-threatening skin conditions and other tumors but also for cosmetic purposes. PDT has negligible effects on underlying functional structures, enabling tissue regeneration feasibility. PDT uses a photosensitizer (PS) and visible light to create cytotoxic reactive oxygen species, which can damage cellular organelles and trigger cell death.