Publications by authors named "L Robles"
C1-2 Stenosis Caused by Posterior Osteophytes: An Unusual Cause of Cord Compression.
World Neurosurg
December 2024
Cervical spinal stenosis most commonly occurs at the subaxial spine. C1-C2 stenosis is relatively unusual but can be present in certain congenital or syndromic conditions such as rheumatoid arthritis. In this manuscript, we highlight the case of a 42-year-old lady who presented with neck pain and signs of high cervical myelopathy.
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- * Research indicates that levels of IRAK-M decrease with age and oxidative stress, with genetic variants linked to a higher risk of developing AMD.
- * Restoring IRAK-M in RPE cells shows promise in protecting against oxidative damage and retinal degeneration, indicating it could be a potential therapeutic avenue for AMD.
Article Synopsis
- Periodontoid pannus formation is typically caused by rheumatoid arthritis and leads to neural compression in the spinal cord, particularly in the retro-odontoid space.
- A case report describes a patient with progressive high cervical myelopathy who was found to have both a retro-odontoid pannus and a posterior mass at C1-C2 leading to severe spinal cord compression.
- The patient underwent successful treatment through a C1-C2 laminectomy and occipitocervical fusion, marking the first reported instance of circumferential pannus at C1-C2 causing such neural compression.
Background: Retrospective data suggest an association between bevacizumab efficacy and the incidence of arterial hypertension (AHT). Additionally, epigenetic mechanisms have been related to AHT.
Methods: This prospective observational study conducted by GEICAM Spanish Breast Cancer Research Group included metastatic breast (MBC) or colorectal (mCRC) cancer patients treated with bevacizumab-containing chemotherapy as first-line treatment.