The axillary lymphoid organ - an external, experimentally accessible immune organ in the zebrafish.

Lymph nodes and other secondary lymphoid organs play critical roles in immune surveillance and immune activation in mammals, but the deep internal locations of these organs make it challenging to image and study them in living animals. Here, we describe a previously uncharacterized external immune organ in the zebrafish ideally suited for studying immune cell dynamics , the axillary lymphoid organ (ALO). This small, translucent organ has an outer cortex teeming with immune cells, an inner medulla with a mesh-like network of fibroblastic reticular cells along which immune cells migrate, and a network of lymphatic vessels draining to a large adjacent lymph sac.

Differences in Social Expectations About Robot Signals and Human Signals.

In our daily lives, we are continually involved in decision-making situations, many of which take place in the context of social interaction. Despite the ubiquity of such situations, there remains a gap in our understanding of how decision-making unfolds in social contexts, and how communicative signals, such as social cues and feedback, impact the choices we make. Interestingly, there is a new social context to which humans are recently increasingly more frequently exposed-social interaction with not only other humans but also artificial agents, such as robots or avatars.

Croizat's form-making, RNA networks, and biogeography.

Advances in technology have increased our knowledge of the processes that effect genomic changes and of the roles of RNA networks in biocommunication, functionality, and evolution of genomes. Natural genetic engineering and genomic inscription occur at all levels of life: cell cycles, development, and evolution. This has implications for phylogenetic studies and for biogeography, particularly given the general acceptance of using molecular clocks as arbiters between vicariance and dispersal explanations in biogeography.