Publications by authors named "L Reggiani-Bonetti"
Article Synopsis
- * Key findings include significant brain abnormalities such as diffuse hypoplasia, nerve cell heterotopies, and immature nerve cells in cerebellar tissue from a newborn affected by the syndrome.
- * These findings highlight the relevance of Cornelia de Lange syndrome as a cohesinopathy and open up discussions on its impact on global intellectual disability in affected patients.
Purpose: Even today, melanoma is a highly aggressive neoplasm with a high mortality rate. The nodular type is very aggressive and has cerebroid nests of melanocytes (CNMs) at the growth edge, morphologically similar to the poorly differentiated neoplastic epithelial cell clusters described in colorectal, breast, and endometrioid endometrial cancers.
Patients And Methods: We selected 25 nodular melanomas (NMs) with known molecular profiles, of which the entire paraffin-embedded lesion was available.
Article Synopsis
- Histopathological examination for cancer is time-consuming, leading to interest in ex-vivo fluorescent confocal microscopy (FCM) as a faster diagnostic tool, particularly for prostate cancer.
- A systematic review analyzed 17 studies on FCM in urology from sources like PubMed and SCOPUS, focusing on its effectiveness in diagnosing prostate cancer and assessing surgical margins.
- FCM showed a high accuracy (85.33% to 95.1%) in differentiating between cancerous and non-cancerous tissues, and its real-time capabilities may reduce the reliance on traditional frozen section analysis during surgeries.
Despite recent advances, biliary tract cancer (BTC) remains one of the most lethal tumor worldwide due to late diagnosis, limited therapeutic strategies and resistance to conventional therapies. In recent years, high-throughput technologies have enabled extensive genome, and transcriptome sequencing unveiling, among others, the regulatory potential of microRNAs (miRNAs). Compelling evidence shown that miRNA are attractive therapeutic targets and promising candidates as biomarkers for various therapy-resistant tumors.
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