Publications by authors named "L Refsgaard"
Background And Purpose: Radiotherapy improves outcomes for breast cancer. However, prior studies have correlated the risk of coronary artery disease (CAD) to the mean heart dose (MHD), mean dose to the left anterior descending artery (LAD_mean) and the left ventricle V5Gy (LV5). Other studies showed an increased risk of CAD for patients with pronounced coronary artery calcification (CAC) at the time of radiotherapy.
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- * The study included nearly 7,000 patients, revealing that the median heart volume increased over time, and the median mean heart dose (MHD) remained low, indicating effective radiation management.
- * Findings suggest that, despite an increase in heart volume, the average heart dose during treatment was minimal, demonstrating the feasibility of large-scale audits with automated tools for better patient care.
Purpose/objective: The Danish Breast Cancer Group (DBCG) IMN2 study investigated the gain from internal mammary node irradiation (IMNI) in node-positive breast cancer patients. IMNI was indicated in right-sided patients, but not in left-sided. Target volume delineations were based on bony landmarks in contrast to the contemporary vessel-based ESTRO consensus guideline.
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- This study focused on training a deep learning model to help doctors identify important areas in breast cancer patients that need treatment.
- It used expert opinions from radiotherapy centers in Denmark to create high-quality data for training the model.
- The results showed that the model's performance was very similar to what experienced doctors would achieve, which means it could be used safely in real medical situations.
Background And Purpose: Guideline adherence in radiotherapy is crucial for maintaining treatment quality and consistency, particularly in non-trial patient settings where most treatments occur. The study aimed to assess the impact of guideline changes on treatment planning practices and compare manual registry data accuracy with treatment planning data.
Materials And Methods: This study utilised the DBCG RT Nation cohort, a collection of breast cancer radiotherapy data in Denmark, to evaluate adherence to guidelines from 2008 to 2016.