Publications by authors named "L Refolo"

Article Synopsis
  • - The article explores the connection between cholesterol levels and Alzheimer's disease, noting early observations of brain amyloid accumulation in those who died from heart attacks and how high cholesterol may accelerate this process.
  • - Research indicates that cholesterol-lowering treatments could potentially reduce amyloid buildup, with evidence suggesting that managing cholesterol in midlife may lower Alzheimer's risk, especially in individuals aged 40 to 55.
  • - While observational studies hint at a protective effect of statins against Alzheimer's, clinical trials show mixed results due to factors like timing, type of statin, and patient selection, leading to a call for exploring alternative treatment targets in cholesterol-related Alzheimer's research.
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Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its clinical spectrum ranges from mild to moderate or severe illness. A 78-year-old male was presented at emergency department with dyspnoea, dry cough and severe asthenia. The nasopharyngeal swab by real-time polymerase chain reaction confirmed a SARS-CoV-2 infection.

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The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT).

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The reproducibility of laboratory experiments is fundamental to the scientific process. There have been increasing reports regarding challenges in reproducing and translating preclinical experiments in animal models. In Alzheimer's disease and related dementias, there have been similar reports and growing interest from funding organizations, researchers, and the broader scientific community to set parameters around experimental design, statistical power, and reporting requirements.

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Alzheimer's disease (AD) is a recognized international public health crisis. There is an urgent need for public and private funding agencies around the world to coordinate funding strategies and leverage existing resources to enhance and expand support of AD research. To capture and compare their existing investments in AD research and research-related resources, major funding organizations are starting to utilize the Common Alzheimer's Disease Research Ontology (CADRO) to categorize their funding information.

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