Tangier disease is an extremely rare autosomal recessive monogenic disorder caused by mutations in the ATP binding cassette transporter A1 gene (ABCA1). It is characterized by severe deficiency or absence of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (ApoA1), with highly variable clinical presentations depending on cholesterol accumulation in macrophages across different tissues. We report a case of a 47-year-old man with very low HDL-C and very high triglyceride levels, initially attributed to the patient's metabolic syndrome, alcohol abuse, and splenomegaly.
View Article and Find Full Text PDFMar Environ Res
January 2025
The antiretroviral therapy program's success in managing the human immunodeficiency virus (HIV) has inadvertently led to the release of antiretrovirals (ARVs) into worldwide aquatic ecosystems. However, few studies investigated the risks of ARV loadings that flow continuously to the marine waters of South America (such as Brazil). Against this backdrop, the aims of this study were: (i) to estimate the Predicted Environmental Concentration (PEC) of thirteen ARVs worldwide used in HIV treatment, and which are frequently disposed of in the marine aquatic ecosystems of Guarujá, São Paulo coastline, Brazil.
View Article and Find Full Text PDFObjective: The objective of this review is to evaluate the effectiveness of interventions to prevent or treat prolonged grief symptoms among families of patients who die in intensive care units (ICU).
Introduction: Up to 52% of families of patients who die in ICU may be at risk of experiencing prolonged grief symptoms.
Inclusion Criteria: Studies of adult family members (≥18 years) of adult ICU patients (≥18 years) who underwent a treatment withdrawal or withholding decision, and who were exposed to tailored interventions to prevent or treat prolonged grief symptoms before, during, and/or after the patient's death will be considered for inclusion.
Aims: Recurrent acute myocardial infarction (RE-AMI) is a frequent complication after STEMI, and its association with stent thrombosis can be life-threatening. Intravenous atorvastatin (IV-atorva) administration during AMI has been shown to limit infarct size and adverse cardiac remodeling. We determined by cardiac magnetic resonance (CMR) whether the cardioprotection exerted by IV-atorva at the index AMI event translates into a better prognosis upon RE-AMI in dyslipidemic pigs.
View Article and Find Full Text PDFIn this study, we explore an enhancement to the U-Net architecture by integrating SK-ResNeXt as the encoder for Land Cover Classification (LCC) tasks using Multispectral Imaging (MSI). SK-ResNeXt introduces cardinality and adaptive kernel sizes, allowing U-Net to better capture multi-scale features and adjust more effectively to variations in spatial resolution, thereby enhancing the model's ability to segment complex land cover types. We evaluate this approach using the Five-Billion-Pixels dataset, composed of 150 large-scale RGB-NIR images and over 5 billion labeled pixels across 24 categories.
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