Effect of anticoagulation on renal function and protein excretion in experimental acute ischemic renal failure.

Female Sprague-Dawley rats underwent right nephrectomy and 40 min left renal artery occlusion (RAO). After 15 min of reflow, polyethylene glycol 1000 (PEG1000) was infused to induce osmotic diuresis and to enable glomerular filtration rate (GFR) measurements. Urine was collected during a 90 min period, and the concentrations of PEG1000, albumin, IgG, IgM and fibrin(ogen)/degradation products (FIB) were assessed both in plasma and urine by radial immuno diffusion technique Groups of rats were subjected to saline + RAO, warfarin + RAO or sham-operation.

Effect of anticoagulation upon nephron obstruction in experimental acute ischaemic renal failure. A morphological study.

Ischaemic-reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline-pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO). After 15 min of reflow, specimens were collected for electron and light microscopic examination.

[Shortcomings in the coverage of death occurring outside hospitals].

The article consists in a report of physicians' observance of legislative requirements concerning the documentation and investigation of deaths outside hospital, as studied in a series of 973 cases of death occurring in four medium-sized Swedish communities during 1993. The results showed manifest shortcomings in the performance of post-mortem investigations: long delays in submitting the death certificate, negligence in reporting unnatural and unexpected deaths to the police, and inadequate notes in the patients' journals concerning death certification, which relatives had been informed, the circumstances of death, and whether post-mortem examination had been performed. A special checklist would be of value in the documentation adn investigation of deaths occurring outside hospital.