Publications by authors named "L Rami"
Article Synopsis
- The study focused on patients with post-acute COVID-19 syndrome (PACS) who have cognitive complaints lasting over 8 weeks after infection.
- Researchers used a combination of neuropsychological tests, health questionnaires, blood samples, and MRI scans over several months to assess cognitive profiles and related biological and psychological factors.
- Results showed high prevalence of attention/executive function (69%) and verbal memory (39%) impairments, along with common issues like apathy (64%) and anxiety (57%), but cognitive evaluations remained stable over time despite no clear link to physical brain abnormalities or severe neuronal damage.
Neurological, psychiatric, and sleep investigations after treatment of anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis in Spain: a prospective cohort study.
Amaia Muñoz-Lopetegi Mar Guasp Laia Prades Eugenia Martínez-Hernández Mireia Rosa-Justícia Lorena Rami
Lancet Neurol
March 2024
Background: Anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis is an autoimmune disorder that can be treated with immunotherapy, but the symptoms that remain after treatment have not been well described. We aimed to characterise the clinical features of patients with anti-LGI1 encephalitis for 1 year starting within the first year after initial immunotherapy.
Methods: For this prospective cohort study, we recruited patients with anti-LGI1 encephalitis as soon as possible after they had received conventional immunotherapy for initial symptoms; patients were recruited from 21 hospitals in Spain.
Article Synopsis
- Alzheimer's disease (AD) and frontotemporal dementia (FTD) exhibit distinct patterns of cortical thickness loss compared to healthy controls, sparking the development of models to analyze individual differences in these conditions.
- The study analyzed data from 379 participants, using structural MRI to create region-wise temporal models of cortical thickness, and examined the correlation of individual deviations with cognitive (MMSE) and biological (NfL, 14-3-3 protein) markers.
- The findings indicate that cortical thickness models can effectively track changes over time in AD and FTD, revealing important associations with cognition and biomarkers, although variability in FTD presented challenges in predicting longitudinal outcomes.
Article Synopsis
- The study addresses the challenges of comparing self-perceived cognitive functioning across various aging studies by linking item-level data from international research.
- The researchers harmonized data from 24 different studies and found that certain items related to memory and executive functions provided the best measurement precision.
- This work allows for better comparison and analysis of cognitive functioning in older adults globally, potentially paving the way for improved self-report questionnaires based on the identified key items.
Article Synopsis
- The study focuses on developing a new 1-week memory battery (1WMB) to assess early memory declines, potentially linked to Alzheimer's disease (AD), specifically targeting cognitively unimpaired individuals.
- The 1WMB evaluates memory through short (20 min) and long-term (1 week) recall, showing higher sensitivity in detecting accelerated long-term forgetting compared to conventional memory tests.
- Results indicate that the 1WMB is a reliable tool for measuring episodic memory and could help identify individuals at risk for AD, though further research is needed to confirm its effectiveness.