Publications by authors named "L Rafael-Valdivia"
High frequency of central memory regulatory T cells allows detection of liver recipients at risk of early acute rejection within the first month after transplantation.
Int Immunol
February 2016
Several studies have analyzed the potential of T regulatory cells (Treg cells) as biomarkers of acute rejection (AR). The aim of the present multicenter study was to correlate the percentage of peripheral Treg cells in liver graft recipients drawn at baseline up to 12 months after transplantation with the presence of AR. The percentage of central memory (cm) Treg cells (CD4(+)CD25(high)CD45RO(+)CD62L(+)) was monitored at pre-transplant and at 1 and 2 weeks, and 1, 2, 3 and 6 months and 1 year post-transplantation.
View Article and Find Full Text PDFArticle Synopsis
- Acute rejection (AR) is a significant challenge in organ transplantation, prompting the search for predictive biomarkers in liver and kidney transplant recipients.
- A multicenter study analyzed various biomarkers, including IFN-γ, IL-17, and IL-2, both before and after transplantation, involving 142 patients (63 liver, 79 kidney), where 28 developed AR.
- The study found that specific intracellular expressions of these biomarkers could predict a high risk of AR, leading to the development of risk prediction models that can inform future treatment strategies and help tailor immunosuppressive therapies.
Biomarker monitoring is needed in transplantation to reflect individual response to immunosuppressive drugs and graft outcome. We evaluated intracellular expression and soluble production of interferon-(IFN)-γ and interleukin-(IL)-2 as predictive biomarkers of acute rejection (AR) and personal drug response. Pharmacokinetic-pharmacodynamic profiles were determined in 47 de novo liver recipients treated with tacrolimus, mycophenolate mofetil and prednisone.
View Article and Find Full Text PDFBackground: Increased blood pressure (BP) is common after liver transplantation. However, there is scarce information on its control.
Methods: In this prospective, cross-sectional, multicenter study, we determined BP according to the recommended international standards in 921 liver transplant patients during one routine outpatient visit to assess their grade of control of BP.
Background And Aim: Delayed introduction of calcineurin inhibitors (CNI) in liver transplantation (OLT) seeks to protect renal function, although the optimal length of the delay is not well established. The aim of this study was to analyze the effects on renal function of CNI initiation on different days after OLT.
Methods: We reviewed the charts of 260 OLT recipients.