Biomarkers.

Background: Down syndrome (DS) is associated with mitochondrial dysfunction leading to higher levels of oxidative stress and cell degeneration. This fact, together with the overexpression of AD-related genes in trisomy 21, increases the risk of developing Alzheimer's disease (AD). Thus, it is important to look for interventions that could prevent mitochondrial damage before symptoms occur.

Biomarkers.

Background: Multiple studies have linked high cortisol levels, a frequently used biomarker of stress, with the Alzheimer's disease (AD) pathophysiology. However, the relationship between cerebrospinal fluid (CSF) cortisol levels and AD-related brain atrophy is not fully understood. This study sought to investigate the cross-sectional and longitudinal association between CSF cortisol levels and brain cortical thickness in patients across the biological and clinical continuum of AD.

Alzheimer's Imaging Consortium.

Background: Multiple studies have linked high cortisol levels, a frequently used biomarker of stress, with the Alzheimer's disease (AD) pathophysiology. However, the relationship between cerebrospinal fluid (CSF) cortisol levels and AD-related brain atrophy is not fully understood. This study sought to investigate the cross-sectional and longitudinal association between CSF cortisol levels and brain cortical thickness in patients across the biological and clinical continuum of AD.

Oral Kaposi sarcoma in Brazil: a case series of 40 patients highlighting a significant health burden.

Objective: The aim of this study was to provide a comprehensive clinicopathological analysis of oral Kaposi sarcoma (KS) cases and examine its relationship with HIV-related immunosuppression.

Study Design: Paraffin-embedded tissue blocks of patients microscopically diagnosed with oral KS were retrieved from three oral and maxillofacial pathology files. Data including clinical, laboratory, microscopic and immunohistochemical findings and treatment employed were retrieved.

Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil.

The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 and over 60 at diagnosis. Forty-two patients under 40 years old (40.