Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction.

The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is essential for correct functioning of innate immune responses. The ADAR1p110 isoform is mainly nuclear and ADAR1p150, which is interferon (IFN) inducible, is predominately cytoplasmic. Using three different methods - co-immunoprecipitation (co-IP) of endogenous ADAR1, Strep-tag co-IP and BioID with individual ADAR1 isoforms - a comprehensive interactome was generated during both homeostasis and the IFN response.

The Clinical Profile of Heatstroke Patients Admitted to the Intensive Care Unit: A Case Series From a Tertiary Care Center in New Delhi, India.

Heat-related illnesses include a spectrum of disorders ranging from heat syncope, muscle cramps, and heat exhaustion to heat emergencies such as heatstroke. Severe heatwaves can lead to extremely high environmental temperatures and a spurt of cases of heat-related illnesses and heatstroke. The incidence of such heat-related medical emergencies was much higher in 2024 compared to previous years throughout North and Central India.

A Comprehensive Approach to Unilateral Cleft Lip and Palate Management through Presurgical Nasoalveolar Molding and Surgical Repair in a Neonate.

This case report details the successful application of nasoalveolar molding (NAM) in a 4-day-old neonate with a complete unilateral cleft lip and palate, showcasing a comprehensive treatment approach involving presurgical NAM and subsequent surgical repair. The NAM technique, pioneered by Barry H. Grayson, utilizes a specialized appliance to shape the alveolar ridge and nasal cartilage concurrently.

Insight into efficient photocatalytic degradation of norfloxacin over a simple, economical biochar-based magnetic photocatalyst under solar illumination: a statistical and experimental approach.

The transformation of residual agricultural solid waste into an efficient value-added carbon product has been an ongoing strategy for solid waste management and a sustainable economy. Meanwhile, the upsurgence of antibiotic contamination in water bodies due to their inadvertent use poses a serious threat to human health and leads to antimicrobial resistance. Hence, to neutralize two evils in one stroke simultaneously, a simple, easy, and cost-effective pea shell-based magnetic photocatalyst (PSMC) has been synthesized and characterized by XRD (X-ray diffraction), VSM (vibrating sample magnetometer), XPS (X-ray photoelectron spectroscopy), TGA (thermogravimetric analysis), and FTIR (Fourier-transform infrared) spectroscopy techniques.