[Changes in hemostasis system in patients with hereditary thrombophilia caused by mutation of blood coagulation factor V ( factor V Leiden)].

Aim: To study the incidence of mutation of Leyden's factor V in patients with venous thrombosis and the hemostatic system in carrier of this genetic defect.

Materials And Methods: A hundred and one patients aged 15-69 years who had venous thrombosis and 10 individuals with mutation of Leyden's factor V without manifestations in the history of thrombosis were examined. Factor V gene mutations and the thrombocyte and plasma links of hemostasis were determined by routine methods.

[A method for determining thrombocyte intravascular activation and its significance for clinical practice].

The authors offer a visual method for assessing the intravascular platelet activation, based on examination under phase-contrast microscope of changes in the shape and relative number of blood platelets in aggregations. Results of examinations of patients with different thrombotic diseases are presented.