Outcomes and prognostic factors in superficial spreading melanoma.

Background: Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM).

Methods: A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used.

Estimation of normalized point-source sensitivity of segment surface specifications for extremely large telescopes.

We present a method which estimates the normalized point-source sensitivity (PSSN) of a segmented telescope when only information from a single segment surface is known. The estimation principle is based on a statistical approach with an assumption that all segment surfaces have the same power spectral density (PSD) as the given segment surface. As presented in this paper, the PSSN based on this statistical approach represents a worst-case scenario among statistical random realizations of telescopes when all segment surfaces have the same PSD.

Approximation of normalized point source sensitivity using power spectral density and slopes of wavefront aberration.

We have investigated two approximation methods for estimating the normalized point source sensitivity (PSSN), which is a recently developed optical performance metric for telescopes. One is an approximation based on the power spectral density (PSD) of the wavefront error. The other is the root-square-sum of the wavefront slope.

Management of recurrent leaks following postinfarction ventricular septal defect repairs.

Ventricular septal rupture (VSR) complicates acute myocardial infarction (AMI) in less than 0.2% of cases and is usually surgically managed by endocardial patch repair with infarct exclusion. Although successful in 80% of cases, failure of patch repair (often because of patch dehiscence) results in attempts at percutaneous closure as reoperative mortality can be as high as 40%.

Anorexia and cachexia in advanced cancer.

During the last days of life, patients experience a myriad of symptomatology. While the exact percentage of patients with cancer affected by anorexia may be subject to debate, there is a clear indication that a significant portion of patients with cancer will at some point in the course of his or her illness suffer the ravages of anorexia and the related progressive weight loss that accompanies it. Anorexia is often related to the tissue wasting process of cachexia, a more severely debilitating condition that may be a contributing factor, or even the primary cause of death, in approximately 20% of cancer patients.