[The study of the interaction of antineoplastic drugs mitoxantrone and ametantrone with DNA using the analysis of changes in circular dichroism spectra].

The influence of the ionic strength and temperature of medium on the changes in the geometry of the double stranded DNA of different nucleotide content upon the formation of complexes with antitumor drugs mitoxantrone and ametantrone was investigated. It is shown that from circular dichroism spectra it is possible to determine the relative intensity of changes in the geometry of DNA double helix upon binding with the drugs investigated. The binding of one ametantrone molecule causes greater changes in the geometry of DNA double helix than the binding of mitoxantrone.

[Comparative study of three antineoplastic alkylating agents on DNA].

The influence of three alkylating anticancer preparations phosphamide, sarcolysine, cyclophosphane on content of the 5-methylcytosine and parameters of the melting DNA of the liver healthy animals and tumor sarcoma 45 was investigated. It was shown, that among the investigated preparations cyclophosphane has stronger anticancer influence and comparatively weaker side effect on DNA liver. We came to the conclusion that it is preferable to use this preparation.

[The effect of local x-irradiation on the excretion of oxyproline].

The dependence of excretion of oxyproline in urine on dosage and damaged area was estimated after local exposure of rat skin to low-energy X-radiation. The pronounced hyperoxyprolineuria was observed throughout the periods of latency and formation of ulceronecrotic skin defects.

[Algimaf treatment of trophic ulcers].

A new biologically active preparation, algimaf, developed at the All-Union Research Institute for Medical Polymers, stimulates the regenerative processes, is characterized by analgesic, antiedematous, manifest antibacterial and hemostatic effects, promotes the formation of hardly visible cicatrices, and is a highly effective means for the management of trophic ulcers of the skin.