Creative virtual engagement: Successes and challenges supporting people with serious mental illness in hybrid Clubhouse environments.

Objective: This study examines adaptations, successes, and persistent challenges engaging members in virtual or hybrid community-based psychosocial rehabilitation centers called Clubhouses.

Methods: Fifteen members and staff from five Clubhouses across two Hawaiian Islands participated in a virtual Photovoice process.

Results: Results illustrated several unexpected positive outcomes from the transition to hybrid or virtual formats including opportunities for growth, learning new technology, cross-Clubhouse collaborations, deepened relationships, and better access to some hard-to-reach members.

Newborn Screening for β-Thalassemia Identifies a Complex Genotype Involving a Novel β-Globin Gene Mutation (:c.336dup).

Newborn screening identified a Chinese-Canadian infant who was positive for possible β-thalassemia (β-thal). Detailed family studies demonstrated that the proband was a compound heterozygote for the Chinese γ(γδβ)-thal deletion and a novel frameshift mutation within exon 3 (:c.336dup), and heterozygous for the Southeast Asian α-thal deletion (--/αα).

β-Thalassemia Caused by a Novel Nonsense Mutation [c.199A > T].

We report two hemoglobinopathy cases involving a novel β-thalassemia (β-thal) nonsense mutation, c.199A > T. One patient had Hb S/β-thal, and a second unrelated patient had Hb D-Punjab/β-thal.

Splice Acceptor Mutation [:c.93-2A > T] in a Patient with Hb S/β-Thalassemia.

We report a case of Hb S/β-thalassemia (Hb S/β-thal) in a patient who is a compound heterozygote for the Hb Sickle mutation (:c.20A > T) and a mutation of the canonical splice acceptor sequence of IVS1 (AG > TG, :c.93-2A > T).