Publications by authors named "L R Mosher"
Article Synopsis
- Zavegepant is a new nasal spray medication designed for acute migraine treatment, and this study aimed to assess its safety over a year for adults experiencing moderate to severe migraines.
- The study involved 603 participants who self-administered zavegepant as needed, reporting an average of 3.1 doses per month, with a low rate of serious adverse events and no deaths.
- Common side effects included dysgeusia (taste issues), nasal discomfort, and nausea, but overall, the treatment was deemed safe and well tolerated.
Background: Cardiovascular disease (CVD) is the second-leading cause of death among Canadians. Clinical practice guidelines suggest that improvements to lifestyle, including dietary intake, can reduce the risk of CVD.
Objectives: The primary aim of the study was to evaluate patient changes in adherence to the Mediterranean Diet (Medi-Diet) from baseline to 4-week and 6-month follow-up after participating in a 4-week, group-based, interdisciplinary cardiovascular health programme run by healthcare professionals (HCPs) in a primary care setting.
Rationale: The prepulse inhibition (PPI) of the startle reflex is the best-established index of sensorimotor gating. We documented that the neurosteroid allopregnanolone (AP) is necessary to reduce PPI in response to D dopamine receptor agonists. Since Sprague-Dawley (SD) rats are poorly sensitive to the PPI-disrupting effects of these drugs, we hypothesized that AP might increase this susceptibility.
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- Intranasal formulations, like zavegepant, offer an alternative treatment for migraine sufferers who can't tolerate oral medications due to side effects like nausea.
- This phase 3 trial involved 1978 adults with moderate to severe migraines, randomly assigning them to receive zavegepant nasal spray or a placebo and assessing outcomes like pain relief and bothersome symptoms after 2 hours.
- The study, conducted at 90 medical centers in the USA, aimed to evaluate the effectiveness, safety, and tolerability of zavegepant compared to placebo for acute migraine treatment.
Ample evidence indicates that environmental stress impairs information processing, yet the underlying mechanisms remain partially elusive. We showed that, in several rodent models of psychopathology, the neurosteroid allopregnanolone (AP) reduces the prepulse inhibition (PPI) of the startle, a well-validated index of sensorimotor gating. Since this GABA receptor activator is synthesized in response to acute stress, we hypothesized its participation in stress-induced PPI deficits.
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