Publications by authors named "L R Moolenaar"

Article Synopsis
  • The first-trimester anomaly scan (FTAS) could help detect serious congenital anomalies early in pregnancy, prompting interest in its regular implementation in healthcare.
  • A literature review found that while FTAS increases anxiety before results are received, anxiety typically returns to baseline if no anomalies are detected; depression levels did not significantly change.
  • Studies on healthcare costs indicated that combining FTAS with a second-trimester scan might identify more anomalies, but this approach would also increase overall costs.
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Article Synopsis
  • A study was conducted to evaluate the effectiveness of home-based monitoring versus hospital-controlled monitoring for frozen-thawed embryo transfer (FET) timing in women undergoing assisted reproductive techniques.
  • The trial involved 1,464 women, randomly assigned to either home-based or hospital-controlled monitoring, and aimed to determine if home monitoring could achieve similar pregnancy rates without needing hospital visits.
  • Results showed nearly identical ongoing pregnancy rates in both groups (20.8% for home-based and 20.9% for hospital-controlled), confirming that home monitoring is a viable alternative without compromising fertility outcomes.
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Objectives: The aim of this study was to analyze morbidity and survival after pelvic exenteration for gynecologic malignancies and evaluate prognostic factors influencing postoperative outcome.

Methods: We retrospectively reviewed all patients who underwent a pelvic exenteration at the departments of gynecologic oncology of three tertiary care centers in the Netherlands, the Leiden University Medical Centre, the Amsterdam University Medical Centre, and the Netherlands Cancer Institute, during a 20-year period. We determined postoperative morbidity, 2- and 5-year overall survival (OS) and 2- and 5-year progression free survival (PFS), and investigated parameters influencing these outcomes.

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Bariatric surgery is the most effective treatment for obesity and improves several manifestations of the metabolic syndrome, including nonalcoholic fatty liver disease. Strict nutritional counseling after bariatric surgery is a key in realizing these outcomes. When postoperative nutrient intake or nutrient uptake is compromised, bariatric surgery can also lead to severe hepatic complications.

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The obesity epidemic has caused a surge in the use of bariatric surgery. Although surgery-induced weight loss is an effective treatment of nonalcoholic fatty liver disease, it may precipitate severe hepatic complications under certain circumstances. Acute liver injury (ALI) and acute liver failure (ALF) following bariatric surgery have been reported in several case series.

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