Publications by authors named "L R McMahon"
Introduction And Objectives: Clozapine is the antipsychotic medication with the greatest efficacy in treatment-resistant schizophrenia (TRS). Unfortunately, clozapine is ceased in approximately 0.2% to 8.
View Article and Find Full Text PDFPatent Review of Novel Biologics Targeting Opioid Use Disorder (2018-2024).
ACS Chem Neurosci
December 2024
Article Synopsis
- In 2023, over 107,000 drug overdose deaths occurred in the U.S., with opioids responsible for approximately 80,000 of these fatalities, primarily due to synthetic opioids like fentanyl.
- New biologics, such as monoclonal antibodies and peptides, are emerging as innovative treatments for opioid overdose and opioid use disorder (OUD) by blocking opioids from affecting the central nervous system and reducing potential for abuse.
- The review highlights recent patents on these biologics and discusses their potential to prevent renarcotization, a risk where overdose patients can relapse into overdosing after being treated with naloxone.
With increased legalization of recreational and medical cannabis, use of this drug is growing rapidly among older adults. As cannabis use can impair cognition in young adults, it is critically important to understand how consumption interacts with the cognitive profile of aged individuals, who are already at increased risk of decline. The current study was designed to determine how cannabis influences multiple forms of cognition in young adult and aged rats of both sexes when delivered via two translationally-relevant routes of administration.
View Article and Find Full Text PDFA Novel Prediction Method for Glaucoma Detection Using Retinographies.
Colomb Caribb Conf
November 2023
Glaucoma, characterized by its damage to the retinal nerve, is one of the most statistically dominant eye diseases in the U.S. It can cause vision loss and blindness by affecting the optic nerve.
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