Publications by authors named "L R Ludemann"
The energy deposition of photons and protons differs. It depends on the position in the proton Bragg peak (BP) and the linear energy transfer (LET) leading to a variable relative biological effectiveness (RBE). Here, we investigate LET dependent alterations on metabolic viability and proliferation of sarcoma and endothelium cell lines following proton irradiation in comparison to photon exposure.
View Article and Find Full Text PDFThe value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the detection of prostate cancer is controversial. There are currently insufficient peer reviewed published data or expert consensus to support routine adoption of DCE-MRI for clinical use. Thus, the objective of this study was to explore the optimal temporal resolution and measurement length for DCE-MRI to differentiate cancerous from normal prostate tissue of the peripheral zone of the prostate by non-parametric MRI analysis and to compare with a quantitative MRI analysis.
View Article and Find Full Text PDF. We evaluate a tracer kinetic model for quantification of physiological perfusion and microvascular residue time kurtosis (RTK) in skeletal muscle vasculature with first pass bolus experiments in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)..
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to quantify skin complications in glioblastoma patients treated with Tumor Treating Fields, radiotherapy, and temozolomide, while also examining the skin-sparing effects of electrode positioning.
- Low-dose cone-beam computed tomography scans were used for precise electrode positioning during treatment and for analyzing dosimetric data to assess skin toxicity.
- The results showed that normal tissue complication probabilities for skin necrosis varied widely among patients, highlighting significant dependence on individual patient factors and treatment scenarios.
Purpose: We evaluated pharmacokinetic models which quantify liver function including biliary elimination based on a dynamic Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) technique with sparse data collection feasible in clinical routine.
Methods: Twelve patients with embolized liver segments following interventional treatment of primary liver cancer or hepatic metastasis underwent MRI. During Gd-EOB-DTPA bolus administration, a 3D dynamic gradient-echo (GRE) MRI examination was performed over approx.