Publications by authors named "L R Lard"
Background: Prevention of rheumatoid arthritis has become a definitive target. However, whether prevention of anti-citrullinated protein antibody (ACPA)-negative rheumatoid arthritis is possible is still unknown. We aimed to assess the efficacy of a 1-year course of methotrexate on the development of rheumatoid arthritis in ACPA-negative people with clinically suspect arthralgia and predicted increased risk of rheumatoid arthritis.
View Article and Find Full Text PDFObjective: Magnetic resonance imaging (MRI) of small joints sensitively detects inflammation. This inflammation, and tenosynovitis in particular, has been shown to predict rheumatoid arthritis (RA) development in arthralgia patients. These data have predominantly been acquired on 1.
View Article and Find Full Text PDFArticle Synopsis
- Rheumatoid arthritis (RA) involves autoantibodies such as RF, anti-CCP2, and anti-CarP, but their link to disease activity and treatment outcomes remains unclear.
- A study examined autoantibody levels in 381 RA patients over a year, finding that levels decreased initially, then rose, and were affected by treatment changes (escalation vs. tapering).
- Ultimately, the study concluded that fluctuations in autoantibody levels did not correlate with disease activity or long-term treatment response, indicating complexities in RA management.
Objectives: To determine the 5-year outcomes of early remission induction therapy followed by targeted treatment aimed at drug-free remission (DFR) in patients with early arthritis.
Methods: In 12 hospitals, 610 patients with early (<2 years) rheumatoid arthritis (RA) or undifferentiated arthritis (UA) started on methotrexate (MTX) 25 mg/week and prednisone (60 mg/day tapered to 7.5 mg/day).
Predictive factors of radiological progression after 2 years of remission-steered treatment in early arthritis patients: a post hoc analysis of the IMPROVED study.
RMD Open
February 2016
Objectives: To identify predictive factors of radiological progression in early arthritis patients treated by remission-steered treatment.
Methods: In the IMPROVED study, 610 patients with early rheumatoid arthritis (RA) or undifferentiated arthritis (UA) were treated with methotrexate (MTX) and a tapered high dose of prednisone. Patients in early remission (disease activity score (DAS) <1.