Associations Between MMPI-2-RF Internalizing RC Scales and Positive Characteristics.

Past studies indicate that the low scores on the MMPI and MMPI-2 Clinical and Content Scales can reflect positive characteristics. It is currently unclear, however, whether scales on the MMPI-2-Restructured Form (MMPI-2-RF) have that ability. Accordingly, we examined whether low scores on Restructured Clinical (RC) Scales assessing internalizing difficulties (i.

Measuring Positive Health Behaviors and Outcomes with Low Scores on MMPI-2-RF Somatic Scales.

Previous empirical studies have established that poor mental and physical health often cooccur. However, positive health behaviors and outcomes have been demonstrated to buffer against psychological dysfunction. Thus, the ability to assess for positive health behaviors and outcomes with instruments commonly used in practice, such as the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), is important.

Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients.

Ibogaine is a psychoactive substance that may reduce opioid withdrawal symptoms. This was the first clinical trial of noribogaine, ibogaine's active metabolite, in patients established on methadone opioid substitution therapy (OST). In this randomized, double-blind, placebo-controlled single ascending-dose study, we evaluated the safety, tolerability, and pharmacokinetics of noribogaine in 27 patients seeking to discontinue methadone OST who had been switched to morphine during the previous week.

Functional neurotoxicity evaluation of noribogaine using video-EEG in cynomolgus monkeys.

Introduction: Continuous video-electroencephalographic (EEG) monitoring remains the gold standard for seizure liability assessments in preclinical drug safety assessments. EEG monitored by telemetry was used to assess the behavioral and EEG effects of noribogaine hydrochloride (noribogaine) in cynomolgus monkeys. Noribogaine is an iboga alkaloid being studied for the treatment of opioid dependence.