Publications by authors named "L R Frankel"
Nutrient deprivation is a major trigger of autophagy, a conserved quality control and recycling process essential for cellular and tissue homeostasis. In a high-content image-based screen of the human ubiquitome, we here identify the E3 ligase Pellino 3 (PELI3) as a crucial regulator of starvation-induced autophagy. Mechanistically, PELI3 localizes to autophagic membranes, where it interacts with the ATG8 proteins through an LC3-interacting region (LIR).
View Article and Find Full Text PDFEndometrial scratching before euploid embryo transfer: a case-control study.
J Assist Reprod Genet
January 2025
Purpose: To evaluate the effect of endometrial scratching on in vitro fertilization (IVF) success rates in women undergoing frozen embryo transfer with preimplantation genetic testing for aneuploidy (PGT-A).
Methods: Biopsy was performed at oocyte retrieval in cases and compared to those who did not undergo scratching (controls). Endpoints included pregnancy loss, total pregnancy, clinical pregnancy rate (CPR), ongoing pregnancy rate/live birth rate (OPR), and the incidence of chronic endometritis (CE).
Unlabelled: This project examines associations of gender and emotions in videos on YouTube Kids, a virtual environment for socialization during middle childhood. We selected YouTube Kids because of its popularity, newness, and absence in previous research on emotion socialization. The top 20 recommended videos were sampled and coded for gender and emotional content, by two independent teams of coders.
View Article and Find Full Text PDFArticle Synopsis
- Patients with pancreatic cancer have a low 5-year survival rate, primarily because they are often diagnosed at advanced stages, prompting research into the potential benefits of vitamin C.
- A national database study analyzed over 83,000 patients to compare the incidence of pancreatic cancer between those who used prescribed vitamin C and those who did not, finding a significant lower incidence in those who took vitamin C.
- Results indicated that patients without vitamin C prescriptions had a higher prevalence of pancreatic cancer and higher healthcare costs, suggesting a possible protective effect of vitamin C that warrants further investigation.