Publications by authors named "L R Del Vecchio"
Purpose: To mitigate ischemia-reperfusion injury (IRI) triggered in solid organ transplant procedures, we aimed to evaluate the effects of multi-organ abdominal ischemic preconditioning (MAIP) in the context of renal IRI.
Methods: An experimental kidney transplant model was conducted. Rats were divided into three groups: an intervention free basal group from which physiological data was collected; a control group (CT), which consisted of transplanted animals without MAIP; and a treated group, in which a MAIP protocol was implemented in the donor during the procurement of the left kidney, monitoring the recipient for 24 hours.
Einkorn ( L. ssp. ) is gaining renewed interest for its high nutritional value and digestibility.
View Article and Find Full Text PDFUpdate on current and emerging treatment paradigms for hyperphosphatemia in chronic kidney disease.
Expert Opin Pharmacother
January 2025
Introduction: Hyperphosphatemia in advanced CKD often accompanies high PTH and FGF23 levels, impaired bone mineralization, ectopic calcifications, and increased cardiovascular risks. Novel treatments are now available to lower serum phosphorus effectively. However, safety, tolerability, and patient adherence must be evaluated to determine the best therapeutic option for hyperphosphatemia.
View Article and Find Full Text PDFArticle Synopsis
- The heart's proper functioning depends on both the central nervous system and its own local neuronal networks, known as the intracardiac nervous system (IcNS), which has not been thoroughly studied.
- This research introduces a detailed classification of the IcNS by using advanced techniques like single-cell RNA sequencing, revealing a surprising variety of neuronal types within it.
- Notably, some identified neurons share characteristics with pacemaker neurons from the central nervous system, highlighting the complexity of the IcNS and its crucial role in maintaining heart rhythm, paving the way for future research on cardiac-related issues.
Background & Aims: A significant number of post fecal immunochemical test (FIT) colonoscopies in European-organized colorectal cancer (CRC) screening programs are performed beyond the recommended 31-day threshold due to overburdened colonoscopy services. We aimed to develop a simple predictive model to stratify CRC risk of FIT+ patients.
Methods: In a cohort of screenees undergoing colonoscopy following a positive (≥20 μg hemoglobin/g feces) OC-sensor FIT result between 2004 and 2019, we derived and validated logistic regression-based models including variables independently associated with CRC and advanced neoplasms.