Publications by authors named "L R Crack"

Bone loss below the level of neurological lesion is a well-known complication of spinal cord injury (SCI). To date, most research has focused on pharmaceutical intervention using antiresorptives to prevent bone loss during the acute phase of SCI; however, limited research has investigated treatments for established osteoporosis during chronic SCI. Romosozumab, a monoclonal antibody with both antiresorptive and anabolic effects, has demonstrated significant increases in BMD for women with established PMO.

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Article Synopsis
  • A study surveyed 138 adults with spinal cord injury (SCI) to assess their knowledge and awareness of bone health, particularly bone mineral density (BMD).
  • Findings revealed that a significant number of participants (20%) had never heard of BMD, and around 70% felt they lacked sufficient knowledge on the subject, despite some having received information during rehabilitation.
  • Most participants expressed concern about low BMD risks and a strong desire for more education on prevention and treatment options, highlighting the importance of bone health education for this group.
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Unlabelled: Rapid bone loss can occur after spinal cord injury (SCI) and a standard of care to prevent or treat this phenomenon is an active area of research. Using advanced analysis techniques, this study demonstrates that zoledronic acid, a possible treatment, prevented loss of bone strength at the hip following SCI.

Introduction: Bone loss below the level of neurological lesion is a well-known complication of spinal cord injury (SCI), and effective preventive treatment for this phenomenon is an active area of research.

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Unlabelled: To investigate stress levels among Canadian female university students and determine cutoff scores for low, moderate, and high stress in this population.

Participants: Hundred female undergraduates, mean age of 20.3 ( = 1.

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Article Synopsis
  • The National Lung Matrix Trial (NLMT) is a UK-wide study focusing on targeted therapies for non-small cell lung cancer (NSCLC) based on specific biomarkers.
  • The Cancer Research UK (CRUK) Stratified Medicine Programme 2 is conducting extensive molecular pre-screening, involving eight drugs and 18 molecular cohorts, to assess promising drug-biomarker combinations for further research.
  • The study employs a flexible Bayesian adaptive design and advanced genetic screening techniques to improve patient outcomes by identifying actionable cohorts and understanding resistance mechanisms.
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