Publications by authors named "L R Cortes"

Article Synopsis
  • Leishmania (Viannia) braziliensis causes various types of leishmaniasis, and the study investigates how different subpopulations (Thor03, Thor10, Thor22) affect disease progression in BALB/c mice.
  • The research found that after three weeks of infection, Thor03 and Thor10 led to larger lesions and influenced immune response markers, showing lower IL-12 and TNF levels, while Thor10 had the highest IL-10 levels.
  • The study concluded that these subpopulations might lead to mild footpad lesions but can persist in lymph nodes, highlighting differences in infection patterns and immune responses among the subpopulations.
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Sacha Inchi oil (SIO) and hybrid palm oil (HPO) are potential sources of unsaturated fatty acids to improve the lipid profile of dairy products. This study evaluated, for the first time, the effects of the daily consumption of yogurts with enhanced fatty acid profiles on plasma lipids related to cardiovascular disease (CVD) risk factors. A pilot, randomized, double-blind, parallel-controlled trial was conducted with 47 participants assigned to three groups: SIO-enriched yogurt (Group A), HPO-enriched yogurt (Group B), and plain yogurt (Group C).

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Menopause affects over a million individuals annually and is characterized by variable and declining ovarian hormones. Decreasing estrogen levels impact energy homeostasis and increases the risk of metabolic disorders. Energy expenditure is largely directed towards thermoregulation, which is modulated in part by estrogen receptor (ER) α expressing neurons in the hypothalamus.

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Ensembl (www.ensembl.org) is an open platform integrating publicly available genomics data across the tree of life with a focus on eukaryotic species related to human health, agriculture and biodiversity.

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GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as new technologies and methodologies allow us to catalog the genome at ever-increasing granularity. In particular, long-read transcriptome sequencing enables us to identify large numbers of missing transcripts and to substantially improve existing models, and our long non-coding RNA catalogs have undergone a dramatic expansion and reconfiguration as a result.

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