Publications by authors named "L R Caley"
Background: Cystic fibrosis (CF) is associated with increased resting energy expenditure. However, the introduction of elexacaftor/tezacaftor/ivacaftor (ETI) has resulted in a paradigm shift in nutritional status for many people with CF, with increase body mass index and reduction in the need for nutritional support. While these changes are likely to reflect improved clinical status and an associated downregulation of energy expenditure, they may also reflect drug-induced alterations in metabolic perturbations within CF cells.
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- The article provides an overview of heat-related illnesses and their impact on public health, emphasizing the seriousness of conditions like heat cramps and heat stroke.
- It discusses the pathophysiology of these conditions, key heat transfer mechanisms, and the role of environmental factors in their development.
- The text also covers differential diagnosis, prevention strategies, and nursing implications, stressing the importance of quick recognition and intervention for effective management.
Inflammation is a key driver in the pathogenesis of cystic fibrosis (CF). We assessed the effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on downregulating systemic and immune cell-derived inflammatory cytokines. We also monitored the impact of ETI therapy on clinical outcome.
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- - The study investigates cutaneous (CL) and mucosal leishmaniasis (ML) cases in mainland Portugal from 2010 to 2020, identifying 43 CL and 7 ML cases, predominantly in immunosuppressed individuals.
- - Most cases were autochthonous, with common symptoms including papules/nodules, particularly on the head, and a varied treatment approach noted, mainly using liposomal amphotericin B for ML.
- - The findings highlight a need for better surveillance, clinical awareness, and diagnostic capabilities for leishmaniasis, advocating a One Health approach to tackle the complexities of the disease in Portugal and globally.
Aim: Expanding and sustaining student nurse placements outside of the acute sector is a universal challenge. This paper aims to evaluate the Care Home Education Facilitator Role introduced in one area of Wales, United Kingdom, and to report on the outcomes achieved from this novel role.
Methods: Semi-structured interviews were undertaken with key stakeholders including the Care Home Education Facilitator postholder leading the pilot, care home managers, higher education institutions' placement managers/coordinators, student nurses and national health service staff.