Publications by authors named "L R Bursch"
Article Synopsis
- - The centromeric histone variant CENP-A is crucial for proper chromosome segregation, and its mislocalization can lead to chromosomal instability, particularly in cancer cells.
- - Ubiquitin-mediated proteolysis, specifically involving E3 ligases like Psh1, helps prevent the mislocalization of CENP-A, and certain mutations can exacerbate issues with protein degradation.
- - Research shows a link between the Dbf4-dependent kinase (DDK) complex and the regulation of CENP-A proteolysis, independent of DNA replication, suggesting new avenues for understanding how to maintain chromosomal stability.
Langerhans cells (LC) are APC that reside at the barrier surfaces. Mice expressing an OVA peptide in the epidermis (K14-OVAp) were used to study CD8(+) T cell responses to an epidermal self-Ag. Earlier results suggested that LC were the predominant APC, inducing a robust T cell response and autoimmunity.
View Article and Find Full Text PDFThere are conflicting data in the literature regarding the role of epidermal Langerhans cells (LC) in promoting skin immune responses. On one hand, LC can be extremely potent APCs in vitro, and are thought to be involved in contact hypersensitivity (CHS). On the other hand, it seems counterintuitive that a cell type continually exposed to pathogens at the organism's barrier surfaces should readily trigger potent T cell responses.
View Article and Find Full Text PDFLangerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is not clear because distinct models of LC depletion resulted in opposite conclusions about their role in contact hypersensitivity (CHS) responses. While comparing these models, we discovered a novel population of LCs that resides in the dermis and does not represent migrating epidermal LCs, as previously thought.
View Article and Find Full Text PDFBackground: The histologic appearance of the repair tissue after articular cartilage resurfacing procedures in humans is not well documented.
Hypothesis: The histologic and immunohistochemical appearance of the repair tissues in failed articular cartilage resurfacing procedures will be similar, regardless of the procedure that was done, and will not resemble normal articular cartilage.
Study Design: Case series; Level of evidence, 4.